Alzheimer’s Reversal for Doctors: Introuction and Orientation

Alzheimer’s Reversal for Doctors:
Introduction and Orientation

by Steven Wm. Fowkes

Welcome to the medical side of Alzheimer’s disease reversal.  Although this is a primarily verbal venue, I’ll start with a simple graphic that helps orient me to the clinical challenge of Alzheimer’s disease, what’s the primary pathology and what secondary pathologies are contributing to the condition?

The necessary and essential factor affecting Alzheimer’s disease is loss of glutathione recycling and release of glutathione-bound mercury.  But there are multiple ways in which this can happen, and there are even more ways in which this can be worsened.  Please add to the following lists.

Four dimensions for reversal of Alzheimer's disease
Four dimensions for reversal of Alzheimer's disease



In this illustration, the contributory causes of Alzheimer’s disease have been broken down into four categories that seem to be conceptually related.  By a quick assessment of each person with Alzheimer’s disease (or some other kind of dementia) a better-than-random guess might be made for what to do first.

[You are welcome to download and print a PDF version of this graphic so that you can refer to it after it has scrolled off the page while you read, or read the other posts that will detail each of these factors individually.]

Bottom-Up Factors

These are the factors that take place within the neurons and glia of the brain, but which may also be taking place in the rest of the body.

Hydration pathologies, for example, rarely affect only one tissue, although symptoms of edema (cellular dehydration) can often be easier to see in the ankles and eyelids than in the brain.  But even though dehydration effects can be seen by imaging techniques (MRI, for example) as brain shrinkage and fluid accumulation, there is no standardized assessment protocol for quantifying such changes such that they can be used to judge clinical progress on a longitudinal basis.  Other options will be provided in subsequent postings.

Top-Down Factors

As life has evolved from single cells into animals, top-down control systems have been implemented.  These factors orchestrate and stabilize the interactions of the many cells of the body to facilitate the health, survivability and reproduction of the animal.  The endocrine part of the neuroendocrine system uses hormones to send messages for coordination of cellular activities, and the neuro part of the neuroendocrine system changes that coordination to adapt to external influences.

With advancing brain development, the proportionate energy requirement for the neuroendocrine system has risen to the point that, in humans, roughly 3% of the body’s mass consumes 20% of the body’s energy.  And since the mind and self reside within the brain milieu, our most precious and deeply held values are a direct consequence of this energy overhead.

The medical side of top-down factors is not only encumbered by the sheer complexity of these systems, but by cultural, social and regulatory pressures that have nothing to do with the scientific or medical questions.  Steroids, for example, are restricted by prejudices created from the second world war against Nazis, then transferred to the Soviet Union during the cold war.  Thyroid hormone is equally politicized.  Although insulin resistance is widely recognized and well respected, there is a near-total disconnect between scientific and medical knowledge on one side and public policy on the other.  The marketing of sugar, high-fructose corn syrup, and refined carbohydrate food products is still running full speed.  And the government health services and their grant-driven scientists still manifest a public-policy pretense that obesity is a matter of sloth and gluttony.  Hopefully, I will be able to add some information about dealing with regulatory barriers to reversing Alzheimer’s disease so that the scientific and medical aspects of the clinical challenge will take precedence.

Lifestyle Factors

I group these lifestyle factors as self-care options that have a poor fit with medical practice.

For example, urine or saliva pH is easy to test in a clinical setting, but a single reading has almost no meaning.  It is the dynamic movement of pH readings and acid and alkaline momentum that have meaning, and multimpe, ongoing readings are needed to provide this content.  So clients have to do this on their own initiative to have access to the data.

You can teach people emotional freedom technique in an office setting, but they have to put it into practice for it to provide results.

There might be some interesting surprises in this category.


This list can go on and on.  There may be some pleasant surprises here.

Stay tuned for more.

For further information, please also review my nine-part YouTube series on Reversing Alzheimer’s disease.  Each part is only ten minutes. This is the best possible foundation for understanding the full implications of these posts.   —Steve

2 thoughts on “Alzheimer’s Reversal for Doctors: Introuction and Orientation”

    1. Ideally, oxidants produce an antioxidant defense. Asea (see earlier blog) contains hypochlorite (chlorine bleach), which is an oxidizing agent that occurs naturally in human metabolism. If the dose of oxidant is within the adaptive capacity of the person, the body makes more of the antioxidant enzymes for detoxifying the oxidant. Antioxidant defenses are a central factor in Alzheimer’s disease, specifically glutathione. So if Asea increases glutathione, it should help reduce Alzheimer’s disease.

      If the oxidant overwhelms the adaptive capacity of the system, there is potential for an opposite reaction. The most common forms of this are 1) exercise over-training, where free radicals from exercise become toxic and result in maladaptation, and 2) medical imaging (X-rays, CAT scans, SPECT scans, etc.), where the oxidant stress is too quick for the body’s systems to adapt. Increased radiation that is gradual can be easily accommodated, like if you moved from San Francisco (sea level) to Denver (a mile high). The radiation doubles, and 99.9% of people adapt seamlessly, with no observable pathology (e.g., cancer).

      There may be other, indirect, effects on energy systems, neuroendocrine regulation and immune function that might also be involved. It is clear that inflammation plays a major role in aggravating Alzheimer’s disease. Oxidants like hypochlorite, hydrogen peroxide, hyperbaric oxygen, ozone, UVI, hypericin, negative ions (superoxide) and nitric oxide may mitigate inflammatory processes.

      Most inflammatory reactions activate aromatase and indoleamine oxidase. Aromatase converts energy-enhancing testosterone and progesterone into energy-sapping estradiol and estrone, which damages antioxidant defenses (NADH generation at the mitochondrial level). Indoleamine dioxygenase catabolizes tryptophan and 5-hydroxytryptophan (5-HTP), which can interfere with sleep, mood and wellbeing, which can further sabotage neuroendocrine regulation. So there are many ways that oxidants and antioxidants might affect Alzheimer’s risks.

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