• Home
  • Joni
  • Steve
  • Contact
  • Login

ProjectWellbeing

You are here: Home / Alzheimer's disease / Niemann Pick Type C and Alzheimer’s ?

Niemann Pick Type C and Alzheimer’s ?

2, September2, 2011 By Steven Fowkes Leave a Comment

Here’s one link I found (out of many) for possible reason and cause for
Alzheimer’s:  http://addiandcassi.com/gleevec-cancer-drug-reported-work-alzheimers-disease-working-niemann-pick-type-mouse

There may be many Alzheimer’s-like diseases.  It is my opinion that the root cause of Alzheimer’s disease is the loss of glutathione recycling and the release of mercury from its glutathione-bound form.  This “loose” mercury poisons all enzymes that contain sulfhydryl (reduced sulfur) groups at their active sites, which includes several phosphatases and kinases, one of which is cited in the Niemann-Pick article you linked.

Since collapse of the glutathione system is the hallmark feature of sudden infant death syndrome and autism, I refer to these as Alzheimer’s like diseases.  But SIDS has no known brain pathology (as separate from death, which could be a brain-specific pathology).  And autism has brain pathology which is very qualitatively distinct from Alzheimer’s disease.  But I predict that we will see “set differences” (in its mathematical meaning) among inhibited sulfhydryl enzymes in these, and other, conditions.

So, for example, for Alzheimer’s disease, there is a catastrophic change in the phosphorylation cycle in the brain.  The kinase enzymes, which phosphorylate enzymes, are dynamically balanced by the phosphatase enzymes, which de-phosphorylate enzymes.  The dynamics is metastable, flipping from an overphosphorylated state to an underphosphorylated state, because kinases phosphorylate phosphatases and kinases, and phosphatases de-phosphorylate phosphatases and kinases.  Some kinases increase their activity when phosphorylated, and others decrease their activity when phosphorylated.  Same for phosphatases.  So the system is always unbalanced, swinging through the average phosphorylation level and correcting towards the other way only after hitting a phosphorylation peak or trough.  In the brain, a subset of these phosphatases and kinases are sulfhydryl enzymes.  So when mercury escapes from glutathione, critical phosphatases and kinases are inhibited which selectively damages the dephosphorylation side of the metastable cycle, pinning it in an overphosphorylated state.  No more cycling.  Overphosphorylated tau protein accumulates and precipitates into neurofibrillary tangles.  This is a mid-term manifestation of Alzheimer’s disease.  Beta-amyloid precipitation is a late stage.

Although the mercury toxicity is not limited to the brain, only the brain has this metastable phosphorylation cycle, which among other things, tightens and relaxes the cytoskeleton.  So the brain shows unique toxicity and symptomatology from this pathology.  I suspect that in autism, the dynamic of immune-mediated feedback between the gut and the brain is selectively sabotaged.  In SIDS, the babies die suddenly, so we don’t know the extent or selectivity of symptoms.  But Archie Kalokerinos, MD (author of the excellent book Every Second Child) was able to prevent 99% of vaccination-induced SIDS by post-vaccination injection of vitamin C, which stabilizes the glutathione system against overload by mercury and/or immune-mediated inflammation.  This is the basis for my recommendation of pre- and post-vaccination C for infants, children and adults facing vaccinations of any kind.

In Pick disease, only one kinase may be malfunctioning.  But this appears to be sufficient to produce Alzheimer’s like symptoms, although there may be an entirely different pathway for the pathology that results.  I suggest that this might be a sub-set of the enzyme inhibition of Alzheimer’s disease that I mentioned above.

If so, the same therapies outlined in my YouTube presentation could be helpful.

The compartmentalization of the glutathione redox crisis on one or both sides of the blood-brain barrier could also be a major confusing factor regarding symptoms.  Many people with Alzheimer’s disease do not seem to have much body pathology.  On the other side, teens with idiopathic dilated cardiomyopathy do not seem to have mental symptoms at all, at least until the acute moment of sudden death (like SIDS?).

That’s all for now.  Please feel free to circulate this email in any way you want.  —Steve

Filed Under: Alzheimer's disease, Smart drugs and nutrients, Steve Fowkes Tagged With: Addi, Alzheimer's disease, autism, Cassi, Every Second Child, glutathione, Kalokerinos, kinases, mercury, Niemann-Pick, phosphatases, SIDS, vaccination protection, vaccinations

About Steven Fowkes

Steve has been studying health, nutrition and metabolism for four decades. More info to come.

Leave a Reply Cancel reply

You must be logged in to post a comment.

Welcome to Project WellBeing

This site is dedicated to health and wellness.

Our blogs deal with nutrition, diet and cooking.

Our blogs discuss exercise, sleep and lifestyle choices.

Our blogs cover nutrients, herbs and pharmaceuticals.

Our blogs delve into diseases and metabolic conditions.

From the physiological to the psychological side of life.

Happiness. Stamina. Mental performance. Sleep.

Plain language. Technical details. Practicality.

To use this site:

1) Read some of the featured articles at left.
2) Know your topic? Do a key-word search above.
3) Curious? Pull down the categories menu from below.
4) Questions? Use the comment feature to ask
5) Use the Site Guide at the very top for helpful suggestions.
6) How to become a guest blogger on this sit

Categories

Sign Up for Mailing List

  • This field is for validation purposes and should be left unchanged.

Meetup Events

May
17
Thu
7:00 pm Smart Life Forum, every 3rd Thur...
Smart Life Forum, every 3rd Thur...
May 17 @ 7:00 pm – 10:00 pm
Project Wellbeing Thursday, May 17 at 7:00 PM Smart Life Forum meets the 3rd Thursday’s of each month, in Palo Alto. Hosted by the Silicon Valley Health Institute, these meetings take place at th… https://www.meetup.com/ProjectWellbeing/events/dhzgphyxhbwb/
May
20
Sun
2:00 pm Self-Care Working Group
Self-Care Working Group
May 20 @ 2:00 pm – 5:00 pm
Project Wellbeing Sunday, May 20 at 2:00 PM Self-care technologies. Figuring out stuff for yourself. What you can learn before you resort to expensive medical testing. $20 per meeting. Practitio… https://www.meetup.com/ProjectWellbeing/events/249109682/
Jun
17
Sun
2:00 pm Self-Care Working Group
Self-Care Working Group
Jun 17 @ 2:00 pm – 5:00 pm
Project Wellbeing Sunday, June 17 at 2:00 PM Self-care technologies. Figuring out stuff for yourself. What you can learn before you resort to expensive medical testing. $20 per meeting. Practitio… https://www.meetup.com/ProjectWellbeing/events/247976037/
Jun
21
Thu
7:00 pm Smart Life Forum, every 3rd Thur...
Smart Life Forum, every 3rd Thur...
Jun 21 @ 7:00 pm – 10:00 pm
Project Wellbeing Thursday, June 21 at 7:00 PM Smart Life Forum meets the 3rd Thursday’s of each month, in Palo Alto. Hosted by the Silicon Valley Health Institute, these meetings take place at th… https://www.meetup.com/ProjectWellbeing/events/dhzgphyxjbcc/
View Calendar
Add
  • Add to Timely Calendar
  • Add to Google
  • Add to Outlook
  • Add to Apple Calendar
  • Add to other calendar
  • Export to XML

Tags

Alzheimer's disease antioxidants autoimmune disease baking soda bamboo bioflavonoids BMR calcium carbon dioxide ceruloplasmin cholesterol coconut oil collagen copper cortisol cysteine D3 DMSO estriol estrogen glutathione glycine hemochromatosis horsetail hydration inflammation iodine lysine magnesium mercury metabolic rate nattokinase neuroprotection pregnenolone progesterone proline silicon T3 T4 testosterone thyroid hormone transdermal copper type-2 copper deficiency vitamin C wellbeing

Copyright 2016 projectwellbeing.com All rights reserved | StudioPress Themes for WordPress | by PomeroyStudios